Responding to Vaccine Safety Signals during Pandemic Influenza: A Modeling Study

Project Title Responding to Vaccine Safety Signals during Pandemic Influenza: A Modeling Study
Date
Monday, December 22, 2014
Location
Description

This article describes a multi-criteria decision analysis model developed to explore regulatory decision-making in the context of emerging vaccine safety signals during a pandemic. The authors simulated vaccine safety surveillance system capabilities and used an age-structured compartmental model to develop potential pandemic scenarios. The authors also used an expert-derived multi-attribute utility function to evaluate potential regulatory responses by combining four outcome measures into a single measure of interest: 1) expected vaccination benefit from averted influenza; 2) expected vaccination risk from vaccine-associated febrile seizures; 3) expected vaccination risk from vaccine-associated Guillain-Barre Syndrome; and 4) expected change in vaccine-seeking behavior in future influenza seasons.

Health Outcome
Guillain-Barré syndrome
febrile seizure
influenza
Corresponding Author

J. C. Maro, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, 401 Park Drive, Suite 401 East, Boston, MA. Email: jmaro@mit.edu

Authors

Judith C. Maro PhD; Dennis G. Fryback PhD; Tracy A. Lieu MD, MPH; Grace M. Lee MD, MPH; David B. Martin MD, MPH

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